diff -up Python-3.11.0a7/Lib/site.py.2~ Python-3.11.0a7/Lib/site.py
--- Python-3.11.0a7/Lib/site.py.2~	2022-04-05 21:54:03.000000000 +0200
+++ Python-3.11.0a7/Lib/site.py	2022-04-07 19:08:48.674408380 +0200
@@ -377,8 +377,15 @@ def getsitepackages(prefixes=None):
     return sitepackages
 
 def addsitepackages(known_paths, prefixes=None):
-    """Add site-packages to sys.path"""
+    """Add site-packages to sys.path
+
+    '/usr/local' is included in PREFIXES if RPM build is not detected
+    to make packages installed into this location visible.
+
+    """
     _trace("Processing global site-packages")
+    if ENABLE_USER_SITE and 'RPM_BUILD_ROOT' not in os.environ:
+        PREFIXES.insert(0, "/usr/local")
     for sitedir in getsitepackages(prefixes):
         if os.path.isdir(sitedir):
             addsitedir(sitedir, known_paths)
diff -up Python-3.11.0a7/Lib/sysconfig.py.2~ Python-3.11.0a7/Lib/sysconfig.py
--- Python-3.11.0a7/Lib/sysconfig.py.2~	2022-04-07 19:08:48.674408380 +0200
+++ Python-3.11.0a7/Lib/sysconfig.py	2022-04-07 19:10:00.549687607 +0200
@@ -103,6 +103,31 @@ if os.name == 'nt':
 else:
     _INSTALL_SCHEMES['venv'] = _INSTALL_SCHEMES['posix_venv']
 
+# backup the original posix_prefix as rpm_prefix
+# RPM packages use it and we need to be able to read it even when changed
+_INSTALL_SCHEMES['rpm_prefix'] = _INSTALL_SCHEMES['posix_prefix']
+# Virtualenv >= 20.10.0 favors the "venv" scheme over the defaults when creating virtual environments.
+# See: https://github.com/pypa/virtualenv/commit/8da79db86d8a5c74d03667a40e64ff832076445e
+# See: https://bugs.python.org/issue45413
+# "venv" should be the same as the unpatched posix_prefix for us,
+# so new virtual environments aren't created with paths like venv/local/bin/python.
+_INSTALL_SCHEMES['venv'] = _INSTALL_SCHEMES['posix_prefix']
+
+if (not (hasattr(sys, 'real_prefix') or
+    sys.prefix != sys.base_prefix) and
+    'RPM_BUILD_ROOT' not in os.environ):
+        _INSTALL_SCHEMES['posix_prefix'] = {
+            'stdlib': '{installed_base}/{platlibdir}/python{py_version_short}',
+            'platstdlib': '{platbase}/{platlibdir}/python{py_version_short}',
+            'purelib': '{base}/local/lib/python{py_version_short}/site-packages',
+            'platlib': '{platbase}/local/{platlibdir}/python{py_version_short}/site-packages',
+            'include':
+                '{installed_base}/include/python{py_version_short}{abiflags}',
+            'platinclude':
+                '{installed_platbase}/include/python{py_version_short}{abiflags}',
+            'scripts': '{base}/local/bin',
+            'data': '{base}/local',
+        }
 
 # NOTE: site.py has copy of this function.
 # Sync it when modify this function.
diff -up Python-3.11.0a7/Lib/test/test_sysconfig.py.2~ Python-3.11.0a7/Lib/test/test_sysconfig.py
--- Python-3.11.0a7/Lib/test/test_sysconfig.py.2~	2022-04-05 21:54:03.000000000 +0200
+++ Python-3.11.0a7/Lib/test/test_sysconfig.py	2022-04-07 19:10:32.618812176 +0200
@@ -333,7 +333,7 @@ class TestSysConfig(unittest.TestCase):
         self.assertTrue(os.path.isfile(config_h), config_h)
 
     def test_get_scheme_names(self):
-        wanted = ['nt', 'posix_home', 'posix_prefix', 'posix_venv', 'nt_venv', 'venv']
+        wanted = ['nt', 'posix_home', 'posix_prefix', 'posix_venv', 'nt_venv', 'venv', 'rpm_prefix']
         if HAS_USER_BASE:
             wanted.extend(['nt_user', 'osx_framework_user', 'posix_user'])
         self.assertEqual(get_scheme_names(), tuple(sorted(wanted)))
@@ -345,6 +345,8 @@ class TestSysConfig(unittest.TestCase):
             cmd = "-c", "import sysconfig; print(sysconfig.get_platform())"
             self.assertEqual(py.call_real(*cmd), py.call_link(*cmd))
 
+    @unittest.skipIf('RPM_BUILD_ROOT' not in os.environ,
+                     "Test doesn't expect Fedora's paths")
     def test_user_similar(self):
         # Issue #8759: make sure the posix scheme for the users
         # is similar to the global posix_prefix one