diff -ruN a/setup.py b/setup.py
--- a/setup.py	2022-06-23 03:21:37.000000000 +0900
+++ b/setup.py	2022-08-05 16:23:28.451466769 +0900
@@ -367,13 +367,13 @@
         sources=["src/CAST.c"],
         py_limited_api=True),
     Extension("Crypto.Cipher._raw_des",
-        include_dirs=['src/', 'src/libtom/'],
+        include_dirs=['src/'],
         sources=["src/DES.c"],
-        py_limited_api=True),
+        extra_link_args=["-ltomcrypt"]),
     Extension("Crypto.Cipher._raw_des3",
-        include_dirs=['src/', 'src/libtom/'],
+        include_dirs=['src/'],
         sources=["src/DES3.c"],
-        py_limited_api=True),
+        extra_link_args=["-ltomcrypt"]),
     Extension("Crypto.Util._cpuid_c",
         include_dirs=['src/'],
         sources=['src/cpuid.c'],
@@ -415,9 +415,9 @@
         sources=["src/ARC4.c"],
         py_limited_api=True),
     Extension("Crypto.Cipher._Salsa20",
-        include_dirs=['src/', 'src/libtom/'],
+        include_dirs=['src/'],
         sources=["src/Salsa20.c"],
-        py_limited_api=True),
+        extra_link_args=["-ltomcrypt"]),
     Extension("Crypto.Cipher._chacha20",
         include_dirs=['src/'],
         sources=["src/chacha20.c"],
diff -ruN a/src/DES.c b/src/DES.c
--- a/src/DES.c	2022-06-23 03:21:37.000000000 +0900
+++ b/src/DES.c	2022-08-05 16:11:49.984484561 +0900
@@ -39,7 +39,7 @@
 
 /* Include the actial DES implementation */
 #define LTC_NO_PROTOTYPES
-#include "libtom/tomcrypt_des.c"
+#include <tomcrypt.h>
 
 struct block_state {
     symmetric_key sk;