--- a/src/hotspot/share/jfr/periodic/sampling/jfrThreadSampler.cpp	2024-01-15 20:35:13.409882846 +0300
+++ b/src/hotspot/share/jfr/periodic/sampling/jfrThreadSampler.cpp	2024-01-15 20:37:08.895609642 +0300
@@ -638,14 +638,18 @@
   if (_instance == NULL && 0 == period) {
     return;
   }
-  instance().set_sampling_interval(true, period);
+  if (_instance) {
+    instance().set_sampling_interval(true, period);
+  }
 }
 
 void JfrThreadSampling::set_native_sample_interval(size_t period) {
   if (_instance == NULL && 0 == period) {
     return;
   }
-  instance().set_sampling_interval(false, period);
+  if (_instance) {
+    instance().set_sampling_interval(false, period);
+  }
 }
 
 void JfrThreadSampling::on_javathread_suspend(JavaThread* thread) {